Donegal GP Dr Denis McCauley says public health teams are now working through close contacts of three confirmed cases of bacterial meningitis - two of which were fatal.
One more report is not confirmed, but has been classed as a 'possible' case of the disease.
Three of the patients are young adults and the other is a child under 10 years old - all are from different areas of Ireland with no links.
Bacterial meningitis is a serious illness that involves the inflammation of the membranes covering the brain and spinal cord - it requires urgent antibiotic treatment.
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