The road between Kinlough and Garrison has reopened following yesterday's fatal collision.
A man in his 20s died in the single vehicle crash which happened in the townland of Derryherk at around 7am yesterday morning.
A woman in her 40s remains in a serious condition in Sligo University Hospital.
A technical examination of the scene has been conducted by Garda Forensic Collision Investigators.
Gardai say that investigations are ongoing and are appealing for any witnesses to come forward.